Search results for "model [particle]"
showing 10 items of 1261 documents
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Principled animation design improves comprehension of complex dynamics
2016
International audience; Learners can have difficulty in decomposing conventionally designed animations to obtain raw material suitable for building high quality mental models. A composition approach to designing animations based on the Animation Processing Model was developed as a principled alternative to prevailing approaches. Outcomes from studying novel and conventional animation designs (independent variable) were compared with respect to mental model quality, knowledge of local kinematics, and capacity to transfer (dependent variables). Study of a compositional animation that presented material in a contiguous fashion resulted in higher quality mental models of a piano mechanism than …
Analysis of Relationship between Net Wage and Consumer Price Index
2013
Abstract In the present paper is presented an econometric analysis of the relationship between net salary and consumer price index. After a brief historical overview will be review the calculating statistics for selected variables and coefficients and will be presented the obtained values. We will study the relationship between variables. It will be realized the cloud of points and will be applied Fisher test. The intensity of selected variables will be study too and some forms of relationship between the two chose variables will be done. Student test is applied. It will be performed the parameter estimation for regression functions and Akaike's criterion will be applied. The homoscedastici…
Data from: Oxygen and carbon isoscapes for the Baltic Sea: testing their applicability in fish migration studies
2018
Conventional tags applied to individuals have been used to investigate animal movement, but these methods require tagged individuals be recaptured. Maps of regional isotopic variability known as “isoscapes” offer potential for various applications in migration research without tagging wherein isotope values of tissues are compared to environmental isotope values. In this study, we present the spatial variability in oxygen (math formula) and dissolved inorganic carbon (δ13CDIC) isotope values of Baltic Sea water. We also provide an example of how these isoscapes can reveal locations of individual animal via spatial probability surface maps, using the high-resolution salmon otolith isotope da…
Association between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and C-reactive protein levels and metabolic status in patients with a bip…
2022
OBJECTIVES Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-Reactive Protein (CRP) are markers of inflammation that are elevated in bipolar disorder (BD) and are also related to a higher risk of metabolic syndrome (MetS). This study aimed at investigating for the first time the association between NLR, PLR, and CRP and the metabolic status in BD. METHODS We assessed the association between biomarkers and the metabolic status: number of metabolic risk factors, presence of MetS, insulin sensitivity (Quantitative Insulin Sensitivity Check Index, QUICKI) and insulin resistance (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR index), in a sample of 219 outpa…
The Phys-Can observational study: adjuvant chemotherapy is associated with a reduction whereas physical activity level before start of treatment is a…
2020
AbstractBackgroundAdjuvant therapy may cause multiple sideeffects on long term health, including reduced cardiorespiratory fitness (CRF) in patients with breast cancer (1, 2). However, there is currently limited knowledge regarding the effect of different types of adjuvant cancer treatment on CRF in other cancer populations. The primary objective of the present study was to assess whether previously known correlates (age, diagnosis, initial CRF, physical activity level), type of adjuvant treatment and cancer-related fatigue were associated with changes in$$ \dot{V}{O}_2\mathit{\max} $$V̇O2maxin patients with breast, prostate or colorectal cancer.MethodsProspective study with two time points…
Effects of training on postural control and agility when wearing socks of different compression levels
2017
Summary Study aim: The aim of this study was to evaluate the effects of training while wearing socks differing in compression level (clinical, sub-clinical, regular) on performance of static and dynamic balancing and agility tasks in healthy, physically active people. We sought to understand whether socks with different compression properties supported postural regulation and agility task performance by enhancing somatosensory perception, unskewed by specific age range effects. Material and methods: Participants comprised 61 adults aged 18-75 years, divided into three groups (two experimental groups wearing clinical or sub-clinical level compression socks, and one control group wearing regu…
Analiza sposobów modelowania reaktora trójfazowego ze stałym złożem (TBR) z użyciem metod CFD
2018
Przedstawiono zagadnienia związane z zastosowaniem modelu wielofazowego Eulera do modelowania reaktora trójfazowego ze złożem stacjonarnym (TBR). Analizując równania modelu wyselekcjonowano parametry, które obliczane są w oparciu o dane dostępne w literaturze, a następnie przeprowadzono analizę czułości modelu na zmianę wartości wyselekcjonowanych parametrów. Przeanalizowano wpływ zmian zależności opisujących siły wzajemnych oddziaływań pomiędzy fazami oraz promieniowej zmiany porowatości wypełnienia na wyniki obliczeń numerycznych.
Modelling biological nitrogen and phosphorus removal with soluble microbial products (SMP) production-degradation processes
2011
Over the last two decades, Membrane Bioreactors (MBR) are increasingly used for wastewater treatment. Mathematical modelling of MBR systems has played a key role in order to better explain the effect of their peculiarities. Indeed, several MBR models have been presented in literature in order to improve the knowledge on MBR systems: biological models, hybrid models which include soluble microbial product (SMP) modelling, physical models able to describe the membrane fouling and integrated models which couple the hybrid models with the physical ones. However, among the existing MBR models only few integrated models have been developed which take into account the existing relationship between…
Curs d'Econometria: part teòrica
2015
El document conté les transparències usades per il·lustrar i complementar les classes teòriques de l'assignatura Econometria, codi 35.820, que s'imparteix en el Grau d'Administració i Direcció d'Empreses de la Universitat de València. És un curs d'introducció a l'Econometria amb sis unitats temàtiques: 1) Models economètrics i dades econòmiques 2) El model de regressió 3) Propietats i hipòtesis en el model de regressió 4) Contrastament de hipòtesis en el model de regressió múltiple 5) Anàlisi de regressió múltiple amb informació qualitativa 6) Incompliment de les hipòtesis bàsiques